{ "_id": "6a105809acfb0bcc41ca31c1", "Package": "pssmooth", "Type": "Package", "Title": "Flexible and Efficient Evaluation of Principal\nSurrogates/Treatment Effect Modifiers", "Version": "1.0.3", "Authors@R": "person(\"Michal\", \"Juraska\", email = \"mjuraska@fredhutch.org\", role = c(\"aut\", \"cre\"))", "BugReports": "https://github.com/mjuraska/pssmooth/issues", "Description": "Implements estimation and testing procedures for\nevaluating an intermediate biomarker response as a principal\nsurrogate of a clinical response to treatment (i.e., principal\nstratification effect modification analysis), as described in\nJuraska M, Huang Y, and Gilbert PB (2020), Inference on\ntreatment effect modification by biomarker response in a\nthree-phase sampling design, Biostatistics, 21(3): 545-560\n. The methods avoid the\nrestrictive 'placebo structural risk' modeling assumption\ncommon to past methods and further improve robustness by the\nuse of nonparametric kernel smoothing for biomarker density\nestimation. A randomized controlled two-group clinical efficacy\ntrial is assumed with an ordered categorical or continuous\nunivariate biomarker response measured at a fixed timepoint\npost-randomization and with a univariate baseline surrogate\nmeasure allowed to be observed in only a subset of trial\nparticipants with an observed biomarker response (see the\nflexible three-phase sampling design in the paper for details).\nBootstrap-based procedures are available for pointwise and\nsimultaneous confidence intervals and testing of four relevant\nhypotheses. Summary and plotting functions are provided for\nestimation results.", "License": "GPL-2", "URL": "https://github.com/mjuraska/pssmooth", "Encoding": "UTF-8", "RoxygenNote": "7.1.1", "Config/pak/sysreqs": "cmake make", "Repository": "https://mjuraska.r-universe.dev", "Date/Publication": "2020-11-18 01:09:16 UTC", "RemoteUrl": "https://github.com/mjuraska/pssmooth", "RemoteRef": "HEAD", "RemoteSha": "a34c0340f315b9ff5d97e09695e54859267b0288", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-09 07:06:47 UTC", "User": "root" }, "Author": "Michal Juraska [aut, cre]", "Maintainer": "Michal Juraska ", "MD5sum": "99379010d7c07df8926dd8487b1dbe53", "_user": "mjuraska", "_type": "src", "_file": "pssmooth_1.0.3.tar.gz", "_fileid": "5f159114a40d3c7e0fe0edeaf5e05cd93eb46ee56148bfdbc692409150c452bc", "_filesize": 199867, "_sha256": "5f159114a40d3c7e0fe0edeaf5e05cd93eb46ee56148bfdbc692409150c452bc", "_created": "2026-05-09T07:06:47.000Z", "_published": "2026-05-22T13:20:09.662Z", "_distro": "noble", "_jobs": [ { "job": 77387782630, "time": 148, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "6893861102" }, { "job": 77387782944, "time": 146, "config": "linux-release-x86_64", "r": "4.6.0", "check": "OK", "artifact": "6893861365" }, { "job": 77387782964, "time": 101, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "OK", "artifact": "6893856375" }, { "job": 77387782488, "time": 113, "config": "macos-release-arm64", "r": "4.6.0", "check": "OK", "artifact": "6893857636" }, { "job": 77387781889, "time": 287, "config": "source", "r": "4.6.0", "check": "OK", "artifact": "6893845934" }, { "job": 77387782033, "time": 105, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "7161498777" }, { "job": 77387782525, "time": 106, "config": "windows-devel", "r": "4.7.0", "check": "OK", "artifact": "6893856773" }, { "job": 77387782754, "time": 107, "config": "windows-oldrel", "r": "4.5.3", "check": "OK", "artifact": "6893856999" }, { "job": 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"role": "Suggests" }, { "package": "rmarkdown", "role": "Suggests" } ], "_owner": "mjuraska", "_selfowned": true, "_usedby": 0, "_updates": [], "_tags": [], "_stars": 0, "_contributors": [ { "user": "mjuraska", "count": 37, "uuid": 9420213 } ], "_userbio": { "uuid": 9420213, "type": "user", "name": "Michal Juraska", "description": "A biostatistician at Fred Hutch" }, "_downloads": { "count": 223, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/pssmooth" }, "_devurl": "https://github.com/mjuraska/pssmooth", "_searchresults": 9, "_rbuild": "4.6.0", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/NEWS.html", "extra/NEWS.txt", "extra/pssmooth.html", "extra/readme.html", "extra/readme.md", "manual.pdf" ], "_homeurl": "https://github.com/mjuraska/pssmooth", "_realowner": "mjuraska", "_cranurl": true, "_releases": [ { "version": "1.0.0", "date": "2018-07-29" }, { "version": "1.0.1", "date": 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