Package: futility
Type: Package
Title: Interim Analysis of Operational Futility in Randomized Trials
        with Time-to-Event Endpoints and Fixed Follow-Up
Version: 0.5
Date: 2026-02-16
Authors@R: c(person("Yingying", "Zhuang", email = "yyzhuang@uw.edu", role = "aut"), person("Michal", "Juraska", email = "mjuraska@fredhutch.org", role = c("aut", "cre")), person("Doug", "Grove", email = "dgrove@scharp.org", role = "ctb"), person("Peter", "Gilbert", email = "pgilbert@scharp.org", role = "ctb"), person("Alexander", "Luedtke", email = "aluedtke@uw.edu", role = "ctb"), person("Sanne", "Roels", email = "sroels4@its.jnj.com", role = "ctb"), person("An", "Vandebosch", email = "AVANDEBO@its.jnj.com", role = "ctb"))
BugReports: https://github.com/mjuraska/futility/issues
Description: Randomized clinical trials commonly follow participants
        for a time-to-event efficacy endpoint for a fixed period of
        time. Consequently, at the time when the last enrolled
        participant completes their follow-up, the number of observed
        endpoints is a random variable. Assuming data collected through
        an interim timepoint, simulation-based estimation and
        inferential procedures in the standard right-censored failure
        time analysis framework are conducted for the distribution of
        the number of endpoints--in total as well as by treatment
        arm--at the end of the follow-up period. The future (i.e., yet
        unobserved) enrollment, endpoint, and dropout times are
        generated according to mechanisms specified in the simTrial()
        function in the 'seqDesign' package. A Bayesian model for the
        endpoint rate, offering the option to specify a robust mixture
        prior distribution, is used for generating future data (see the
        vignette for details). Inference can be restricted to
        participants who received treatment according to the protocol
        and are observed to be at risk for the endpoint at a specified
        timepoint. Plotting functions are provided for graphical
        display of results.
License: GPL-2
URL: https://github.com/mjuraska/futility
Encoding: UTF-8
RoxygenNote: 7.3.2
Imports: graphics, stats, utils
Suggests: knitr, rmarkdown
VignetteBuilder: knitr
Repository: https://mjuraska.r-universe.dev
Date/Publication: 2026-02-16 22:46:22 UTC
RemoteUrl: https://github.com/mjuraska/futility
RemoteRef: HEAD
RemoteSha: 5418eb4aafd8d333914809746a13bce0b0b76fda
NeedsCompilation: no
Packaged: 2026-06-22 07:11:24 UTC; root
Author: Yingying Zhuang [aut],
  Michal Juraska [aut, cre],
  Doug Grove [ctb],
  Peter Gilbert [ctb],
  Alexander Luedtke [ctb],
  Sanne Roels [ctb],
  An Vandebosch [ctb]
Maintainer: Michal Juraska <mjuraska@fredhutch.org>