# -------------------------------------------- # CITATION file created with {cffr} R package # See also: https://docs.ropensci.org/cffr/ # -------------------------------------------- cff-version: 1.2.0 message: 'To cite package "pssmooth" in publications use:' type: software license: GPL-2.0-only title: 'pssmooth: Flexible and Efficient Evaluation of Principal Surrogates/Treatment Effect Modifiers' version: 1.0.3 identifiers: - type: doi value: 10.32614/CRAN.package.pssmooth abstract: 'Implements estimation and testing procedures for evaluating an intermediate biomarker response as a principal surrogate of a clinical response to treatment (i.e., principal stratification effect modification analysis), as described in Juraska M, Huang Y, and Gilbert PB (2020), Inference on treatment effect modification by biomarker response in a three-phase sampling design, Biostatistics, 21(3): 545-560 . The methods avoid the restrictive ''placebo structural risk'' modeling assumption common to past methods and further improve robustness by the use of nonparametric kernel smoothing for biomarker density estimation. A randomized controlled two-group clinical efficacy trial is assumed with an ordered categorical or continuous univariate biomarker response measured at a fixed timepoint post-randomization and with a univariate baseline surrogate measure allowed to be observed in only a subset of trial participants with an observed biomarker response (see the flexible three-phase sampling design in the paper for details). Bootstrap-based procedures are available for pointwise and simultaneous confidence intervals and testing of four relevant hypotheses. Summary and plotting functions are provided for estimation results.' authors: - family-names: Juraska given-names: Michal email: mjuraska@fredhutch.org preferred-citation: type: manual title: 'pssmooth: Flexible and Efficient Evaluation of Principal Surrogates/Treatment Effect Modifiers' authors: - family-names: Juraska given-names: Michal email: mjuraska@fredhutch.org year: '2019' notes: R package version 1.0.3 repository: https://mjuraska.r-universe.dev repository-code: https://github.com/mjuraska/pssmooth commit: a34c0340f315b9ff5d97e09695e54859267b0288 url: https://github.com/mjuraska/pssmooth contact: - family-names: Juraska given-names: Michal email: mjuraska@fredhutch.org